Correlation between lethal toxin-neutralizing antibody titers and protection from intranasal challenge with Bacillus anthracis Ames strain spores in mice after transcutaneous immunization with recombinant anthrax protective antigen.

نویسندگان

  • Kristina K Peachman
  • Mangala Rao
  • Carl R Alving
  • Robert Burge
  • Stephen H Leppla
  • Venigalla B Rao
  • Gary R Matyas
چکیده

Transcutaneous immunization of mice with recombinant protective antigen (rPA) of Bacillus anthracis resulted in significantly higher lethal toxin-neutralizing antibody titers than did intramuscular injection of alum-adsorbed rPA. Immunized mice were partially protected against intranasal challenge with 235,000 (10 50% lethal doses) Ames strain B. anthracis spores. A highly significant correlation was observed between toxin-neutralizing antibody titer and survival after challenge. Future experiments with rabbits and nonhuman primates should confirm the significance of protection by this vaccine strategy.

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عنوان ژورنال:
  • Infection and immunity

دوره 74 1  شماره 

صفحات  -

تاریخ انتشار 2006